Anaesthesia and pain research at Subiaco

The St John of God Subiaco Hospital Anaesthesia and Pain Research Group is the leading site for delivering high quality multicentre clinical trials in anaesthesia, pain and perioperative medicine. 

Chronic post-surgical pain (CPSP) is now known to be one of the most common complications of major surgery. Rates are variable and surgery specific, ranging from as low as 10% to as high as 70% with a significant neuropathic component and reduction in quality of life. The University of Melbourne has calculated the likely cost of CPSP to the Australian community is approximately $3 billion.

Research generating knowledge in post-surgical pain attempts to understand the mechanisms, complexities, incidence and prevalence of pain, and to reduce the individual burden and societal and economic costs associated with this.
Professor Tomás Corcoran

Research Nurses
Yvonne Buller
Natalie Hird
Short, T. G., Campbell, D., Frampton, C., Chan, M.,
Myles, P. S., Corcoran, T. B., Sessler, D. I., Mills, G. H., Cata, J. P., Painter, T., Byrne, K., Han, R., Chu, M., McAllister, D. J., Leslie, K., Australian and New Zealand College of Anaesthetists Clinical Trials Network, & Balanced Anaesthesia Study Group (2019). Anaesthetic depth and complications after major surgery: an international, randomised controlled trial. Lancet (London, England), 394 (10212), 1907–1914. doi. org/10.1016/S0140-6736(19)32315-3

Ho, K. M., Rao, S., Honeybul, S., Zellweger, R., Wibrow, B., Lipman, J., Holley, A., Kop, A., Geelhoed, E., Corcoran, T., Misur, P., Edibam, C., Baker, R. I., Chamberlain, J., Forsdyke, C., & Rogers, F. B. (2019). A Multicenter Trial of Vena Cava Filters in Severely Injured Patients. The New England Journal of Medicine, 381 (4), 328–337.

Corcoran, T. B., Myles, P. S., Forbes, A. B., O’Loughlin, E., Leslie, K., Story, D., Short, T. G., Chan, M. T., Coutts, P., Sidhu, J., Cheng, A. C., Bach, L. A., Ho, K. M., & Australian and New Zealand College of Anaesthetists Clinical Trials Network (ANZCA), and the Australian Society for Infectious Diseases (ASID) Clinical Research Network (2019). The
perioperative administration of dexamethasone and infection (PADDI) trial protocol: rationale and design of a pragmatic multicentre non-inferiority study. BMJ Open, 9 (9), e030402. bmjopen-2019-030402

Bailey, M. A., Toner, A. J., & Corcoran, T. B. (2020). A survey of perioperative intravenous lidocaine use by anaesthetists in Australia and New Zealand. Anaesthesia and Intensive Care, 48 (1), 53–58. 
doi. org/10.1177/0310057X19889367

Barnes, J., Hunter, J., Harris, S., Shankar-Hari, M., Diouf, E., Jammer, I., Kalkman, C., Klein, A. A., Corcoran, T., Dieleman, S., Grocott, M., Mythen, M. G., & StEP-COMPAC group (2019). Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: infection and sepsis. British Journal of Anaesthesia, 122 (4), 500–508.