Orthopaedics research at Murdoch

• Knee replacement surgery is a common orthopaedic procedure, with about 50,000 total knee replacements occurring in Australia last year. This number is rising each year in line with our ageing population.
• Orthopaedic research is particularly important as there is an increasing number of technologies and equipment available in this field. Therefore assessing patient outcomes (including recovery times, mobility, complications and time spent in hospital) ensures this technology is used effectively.
• Furthermore, medication to assist recovery and care is important for patients undergoing knee and hip replacements. Optimal use of medication ensures patients have reduced pain levels and improved mobility after surgery.

• Radiological and clinical outcomes of joint replacement and knee cartilage repair surgery.
• Computer navigation and clinical outcomes in shoulder replacement surgery.

Computer navigation of reverse total shoulder arthroplasty: the learning curve
The aim of this project is to explore the application of computer navigation in reverse total shoulder arthroplasty (RSA) and to determine its learning curve, safety and accuracy.

The knee stress test: a proposed test for assessing patient outcomes in knee arthroplasty using a bicycle power meter
This study examines a new method to test muscle power using a bicycle power meter. The first phase of the study examines the reliability of this new test in healthy control participants. The second phase of the study involves assessing the post-operative recovery of participants undergoing a total knee replacement (TKR). Participants will be followed for one year to assess the recovery of their leg muscle power and function.

Patient satisfaction following plantar fasciotomy
With the efficacy of surgical treatment for plantar fasciitis not established, it is important to determine its success through long-term patient reported outcome and satisfaction levels following surgery. The aim of this study was to investigate patient satisfaction and quality of life following plantar fasciotomy.

Clinical and radiological outcomes using the Absolut femoral prosthesis and the Global cup system
This study evaluates post-operative radiology and clinical outcomes in patients who undergo primary total hip replacement using the Absolut femoral stem and Global acetabular cup. Patients will be recruited over a two year period and followed up to 10 years after surgery.

Multi-Center Clinical Evaluation of the ATTUNE® Revision System in the Revision Total Knee Arthroplasty
Five-year, prospective, multi-center, non-randomized, non-controlled study of the ATTUNER Revision total knee prostheses, utilizing the fixed bearing (FB) and rotating platform (RP) tibial component with the posterior stabilizing (PS) femoral component in revision total knee arthroplasty (TKA).

Multi-Center Clinical Evaluation of the ATTUNE® Revision System in Complex Primary Total Knee Arthroplasty
Five-year, prospective, multi-center, non-randomized, non-controlled study of the ATTUNER Revision total knee prostheses, utilizing the fixed bearing (FB) and rotating platform (RP) tibial component with the posterior stabilizing (PS) femoral component in complex primary total knee arthroplasty (TKA).

Cartilage repair registry
The purpose of the cartilage repair registry is to improve and maintain the quality of care for individuals receiving cartilage repair surgery. The aim is to capture data on all patients undergoing cartilage repair surgery to objectively determine their functional outcomes using condition specific patient-reported outcome measures.

A comparison of functional outcomes at baseline and three months post knee arthroscopy: a pilot study
Arthroscopy is an important and commonly performed orthopaedic procedure in Australia and considered the gold standard in the diagnosis of meniscal and ligamentous injury. Large numbers of arthroscopies are performed at St John of God Murdoch Hospital yet no evaluation of patient reported functional outcomes has been undertaken. This study aimed to document patient self-reported functional outcomes at three months post arthroscopy using a validated tool and demonstrate feasibility of undertaking these post-operative evaluations.

Partial versus total knee replacement: a single surgeon retrospective study
This study aimed to investigate differences between total knee replacement (TKR) and partial knee replacement in today’s technological setting.

 

St John of God Murdoch Hospital

Mr Ben Jeffcote – Orthopaedic Surgeon & MCOR Director
Professor Allan Wang – Orthopaedic Surgeon & MCOR Director
Professor Piers Yates - Orthopaedic Surgeon
Mr Mark Hurworth – Orthopaedic Surgeon
Rebekah Gibbons - Orthopaedic Research Officer
Dr Katherine Mackie – Orthopaedic Research Officer

Hayes A, Mackie K, Wang AW (2019) Novel 3-D computer tomography evaluation of glenoid implant placement in reverse shoulder arthroplasty. Biomedical Journal of Scientific and Technological Research. 14, 10813-10816.

Wang AW, Mackie K, Breidahl W, Zheng MH. Autologous tenocyte implantation for lateral epicondylitis. In: Surgical Techniques for Trauma and Sports Related Injuries of the Elbow. Springer Verlag, 2019.

MacInnes SJ, Mackie K, Titchener A, Gibbons R, Wang AW. (2019) Activity following reverse total shoulder arthroplasty: What should surgeons be advising? Shoulder and Elbow. 11, 4-15. DOI: 10.1177/1758573218793648

Wang AW, Hayes A, Gibbons R, Mackie K. (2019) Computer navigation of the glenoid component in reverse total shoulder arthroplasty: a clinical trial to evaluate the learning curve. In review.

Gibbons R, Mackie K, Hince D, Hurworth M. (2019) The knee stress test: assessing reliability of a novel test for knee function. In review.

Gibbons R, Mackie K, Beveridge T, Hince D, Ammon P. (2018) Evaluation of long-term outcomes following plantar fasciotomy. Foot and Ankle International. 39, 1312-1319.

Jones CW, Spasojevic S, Goh G, Joseph Z, Wood DJ, Yates PJ. (2018) Wound discharge after pharmacological thromboprophylaxis in lower limb arthroplasty. Journal of Arthroplasty. 33, 224-229.

Edwards P; Ebert J; Wang A; Ackland T. (2018) Effectiveness of formal physical therapy following total shoulder arthroplasty: a systematic review. Shoulder and Elbow. DOI:10.1177/1758573218812038.

Wang A, Lee C, Hughes J, Zheng MH. (2018) Can shoulder arthroscopy work? Letter to the Editor. The Lancet. 39, 2281.

Wang T, Thien C, Wang C, Ni, M, Gao J; Wang A, Jiang Q, Tuan RS, Zheng Q, Zheng MH. (2018) 3D uniaxial mechanical stimulation induces tenogenic differentiation of tendonderived stem cells through a PI3K/AKT signaling pathway. FASEB Journal. 32, 4804-4814.

Wang T, Chen P, Zheng M, Wang A, Lloyd D, Leys T, Zheng Q, Zheng MH. (2018) In vitro loading models for tendon mechanobiology. Journal of Orthopaedic Research. 36, 566-575.

Wang A, Nogrady B. (2018) Sub-acromial shoulder pain: study finds limited benefits from surgery. Medicine Today.19, 9-10.

Kent M, Calvert N, Blades K, Swann A, Yates P. (2017) Enhanced recovery principles applied to revision hip and knee arthroplasty reduces length of stay and Blood transfusion. Journal of Orthopaedics. 14, 555-60.

Kent M, Calvert N, Blades K, Swann A, Yates P (2017). A prospective evaluation of proximal hamstring tendon avulsions: improved functional outcomes following surgical repair.

Knee Surgery Sports Traumatology Arthroscopy. 25, 1943-1950.

Wang A. (2017) Repeated PRP injections after arthroscopic supraspinatus repair provided no additional benefit. Orthopedics Today. 12.

Ebert J, Wang A, Smith A, Nairn R, Breidahl W, Zheng M, Ackland T. (2017) A midterm evaluation of postoperative platelet-rich plasma injections on arthroscopic supraspinatus repair: a randomized controlled trial. American Journal of Sports Medicine. 45, 2965-2974.

Wu JP, Swift BJ, Becker T, Squelch A, Wang A, Zheng YC, Zhao X, Xu J, Xue W, Zheng M, Lloyd D, Kirk TB. (2017) High-resolution study of the 3D collagen fibrillary matrix of Achilles tendons without tissue labelling and dehydrating. Journal of Microscopy. 266, 237-287.

Pang X, Wu JP, Allison GT, Xu J, Rubenson J, Zheng MH, Lloyd DG, Gardiner B, Wang A, Kirk TB. (2017) Three dimensional microstructural network of elastin, collagen, and cells in
Achilles tendons. Journal of Orthopaedic Research. 35, 1203-1214.

Edwards P. Ebert J, Littlewood C, Ackland T, Wang A. (2017) A systematic review of EMG studies in normal shoulders to inform postoperative rehabilitation following rotator cuff repair. Journal of Orthopaedic and Sports Physical Therapy. 47, 931-944.

Zheng MH, Wang A, Wang T, Thien C, Gao J, Zheng Q, Ebert J. (2017) AKT activation by uni-axial mechanical stimulation is essential for repair of micro damages in tendon during daily activities. Journal of Science and Medicine in Sport. 20(Suppl. 3), 39.